Innovative immunomodulatory adhesive systems with anti-inflammatory cytokine release capacity

Anti-Inflammatory, Immunomodulatory, and Tissue Repair Activity on Human Keratinocytes by Green Innovative Nanocomposites

The use of raw materials obtained by waste and processed through innovative industrial methodologies has generated an industry of about a trillion dollars in a short time, and in the near future will provide resources and services for the conservation and sustainable use of natural resources in order to ensure a better and fairer welfare for the human race. The production of nano-fiber chitin n...

Immunomodulatory and anti-inflammatory properties of macrolides

Macrolides are a group of antibiotics whose activity is ascribable to the presence of the macrolide ring, a large macrocyclic lactone ring, to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The most commonly used macrolides have 14 (e.g. erythromycin, clarithromycin, roxithromycin) or 15 (e.g. azithromycin) atoms attached to their macrocyclic ring and therefo...

Immunomodulatory Mechanism Cytokine Production: A Novel Innate Magnesium Decreases Inflammatory

Magnesium decreases inflammatory cytokine production: a novel innate immunomodulatory mechanism.

MgSO(4) exposure before preterm birth is neuroprotective, reducing the risk of cerebral palsy and major motor dysfunction. Neonatal inflammatory cytokine levels correlate with neurologic outcome, leading us to assess the effect of MgSO(4) on cytokine production in humans. We found reduced maternal TNF-α and IL-6 production following in vivo MgSO(4) treatment. Short-term exposure to a clinically...

Immunomodulatory and anti-inflammatory effects of chondroitin sulphate

Chondroitin sulphate (CS) is a natural glycosaminoglycan present in the extracellular matrix and is formed by the 1-3 linkage of D-glucuronic acid to N-acetylgalactosamine. In chondrocytes, CS diminishes interleukin-1 beta(IL-1beta)-induced increases in p38 mitogen-activated protein kinase (p38MAPK) and signal-regulated kinase 1/2 (Erk1/2) phosphorylation, and decreases nuclear factor-kappaB (N...